BioJapan2025 Exhibition Highlights
| No | Title | Department | Researcher in charge | Comment |
|---|---|---|---|---|
| ① | Human iPS cell-derived intestinal epithelial cells | Graduate School of Pharmaceutical Sciences | Hiroyuki Mizuguchi | These intestinal epithelial cells have significantly improved functionality compared to commercially available products, and can be used stably at a low cost through intestinal organoid culture. Currently, many companies are beginning to utilize these cells in research such as pharmacokinetic studies. |
| ② | Development of risk assessment tool for ischemic stroke in cancer patients | Graduate School of Medicine | Tomohiro Kawano | Cancer patients have increased risk of ischemic stroke compared to general population. We developed a risk assessment tool (AHAND score) for ischemic stroke in cancer patients. AHANDS score can identify patients at high risk for ischemic stroke within 2 years from cancer diagnosis, leading to the development of a future, effective preventive therapy for ischemic stroke in cancer patients. |
| ③ | Genetic engineering experiment set using Thermus thermophilus model microorganism | International Center for Biotechnology (ICBiotech) | Kentaro Miyazaki |
This article introduces the competent cell and the new shuttle vector for Thermus thermophilus, |
| ④ | Cancer risk prediction via detection of preceding immune function decline | Graduate School of Medicine | Yusuke Oji |
This is a very unique biomarker that serves as an indicator of basic immune function against cancers.This marker detects immune function decline to assess the risk of cancer development using an antibody against a latently infecting virus. |
| ⑤ | Development of non-invasive evaluation of spermatogenesis using Cr-CEST MRI | Graduate School of Medicine |
Hidetaka Kioka Norichika Ueda |
In male infertility, it is important to evaluate the ability of the testes to produce sperm (spermatogenesis). We have developed a non-invasive method to assess spermatogenesis by measuring creatine levels in the testes using MRI, and we would like to introduce it here. |
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⑥ |
Boosting HDR for Smarter Genome Control | Graduate School of Engineering Science |
Keiichiro Suzuki |
We have established a new method that significantly improves HDR efficiency in dividing cells by combining specific enzyme inhibitors with modifications to donor DNA. This technique achieves high editing accuracy and reproducibility, with broad applications in knock-in system construction and gene function analysis. It is also suitable for development as a research reagent, offering a versatile gene editing approach for various cell experiments. |
| ⑦ | Engineering Long-Lasting In Vivo Bio-Pharmaceutical Expression Through HITI | Graduate School of Engineering Science |
Keiichiro Suzuki |
We developed a secretion-type expression cassette optimized for the HITI method, enabling gene delivery into non-dividing and terminally differentiated cells. By combining a signal peptide and cleavage site in the donor DNA, efficient insertion and precise secretion control are achieved. This system enables sustained in vivo production of biopharmaceuticals and shows promise for gene therapy, drug delivery, and as a research reagent. Validation was conducted using Exendin-4 (Exe4). |
| ⑧ | PF4 as a Novel Target for Cancer Therapy | Research Institute for Microbial Diseases |
Masahiro Yamamoto |
The advent of immune checkpoint inhibitors has revolutionized cancer therapy. However, their clinical application is often limited by immune-related adverse events, particularly the induction of autoimmune diseases. Here, Yamamoto and colleagues identified platelet factor 4 (PF4) as a novel therapeutic target through analyses using a specialized mouse model. PF4 demonstrated robust anti-tumor efficacy without triggering autoimmunity. These findings suggest that PF4 may serve as a central component of next-generation cancer immunotherapy. |
| ⑨ | Efflux Pump Inhibition as a Weapon Against Multidrug-Resistant Bacteria | Institute of Scientific and Industrial Research |
Kunihiko Nishino |
We developed a novel compound that selectively inhibits antibiotic efflux pumps, a major cause of multidrug-resistant hospital infections. This inhibitor lacks inherent antibacterial activity, minimizing resistance development and offering safety advantages. It targets multiple efflux pumps, addressing broad drug resistance and enabling the reuse of existing antibiotics, thereby greatly expanding treatment options. |
| ⑩ | ‐Boosting Cardiac Differentiation Efficiency－ Optimized Culture of Canine iPS Cells |
WPI Premium Research Institute for Human Metaverse Medicine |
Toshiya Nishimura |
Dogs naturally develop diseases similar to those in humans, making them valuable disease models. However, stable generation of canine iPS cells has been challenging. In this study, we successfully established stable canine iPS cell cultures using AR medium containing Activin and Wnt inhibitors. These cells efficiently differentiated into cardiomyocytes, forming beating cardiac tissue. This technology offers a promising platform for heart disease modeling, regenerative medicine, and clinical veterinary applications. |
| ⑪ | mGluR5 as a therapeutic target for TDP-43-related ALS | Graduate School of Medicine |
Seiichi Nagano |
Focusing on TDP-43 pathology, a hallmark of ALS, we explored a novel therapeutic strategy targeting the glutamate receptor mGluR5. snRNA-seq analysis revealed significant upregulation of mGluR5 in the dorsal root ganglia (DRG) of ALS patients. Furthermore, mGluR5 inhibition showed neuroprotective effects in a TDP-43 model with impaired neurite outgrowth. These findings suggest that mGluR5 may be involved in TDP-43-related pathology and represent a promising disease-modifying therapeutic target for ALS. |
| ⑫ | Boosting DCD Heart Transplantation with Ex Vivo Perfusion | Graduate School of Medicine |
Saito Shunsuke |
Transplantation from donation after circulatory death (DCD) is gaining attention; however, its implementation in Japan remains limited due to technical challenges. Our group is developing an ex vivo perfusion system that enables reperfusion and functional assessment of DCD hearts, which holds significant potential to advance the clinical application of heart transplantation. |
| ⑬ | Introduction to Two-Cell Analysis Technology | SANKEN |
Satoshi Yamaguchi |
This is an introduction to a dual-cell analysis system that utilizes a novel patented technology enabling natural semi-fixation of cells via laser irradiation. It allows long-term observation of interactions among numerous cells on a substrate, followed by recovery and analysis of cells of interest.By analyzing time-series images of cells with AI, it identifies characteristic interactions, enabling their recovery for RNA sequencing analysis.It is ideal for exploring novel immune cells acting on research targets, as well as identifying genes, antibodies, and other factors influencing cell-cell interactions. |
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E-mail: biojapan2025[★]uic.osaka-u.ac.jp
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