Title list by research areas [The University of Osaka Biomedical R&D Seeds 2025]

• Drugs (Cancer)
• Drugs (Brain and Psychiatry)
• Drugs (Intractable diseases)
• Drugs (Cardiovascular diseases)
• Drugs (Infectious diseases)
• Drugs (Others)
• Medical devices
• Regenerative medicine
• Diagnostics

Drugs (Cancer)

• Development of the new anti-cancer medicine targeting GREB1, a novel Wnt signal-related molecule (Center for Infectious Disease Education and Research, Specially Appointed Professor Akira KIKUCHI, Graduate School of Biomedical Sciences, Tokushima University, Professor Shinji MATSUMOTO)
• Research and development of intellectual property for epigenomic drug discovery that dually targets cancer stem cells and cancer immunity (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Maximizing cost-effectiveness by conjugating modifications for clinical application of innovative nucleic acid drugs (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Development of anti-cancer drug targetting CKAP4 (Center for Infectious Disease Education and Research, Specially Appointed Professor Akira KIKUCHI)
• Rapid clinical application of specific inhibitors targeting refractory gastrointestinal cancer stem cells (Department of Medical Data Science, Graduate School of Medicine, Professor Hideshi ISHII)
• Development of Nucleic Acid Lipid Nanoparticles with Anticancer Effects (Research Institute for Microbial Diseases, Guest Professor, Graduate School of Biomedical Sciences, Nagasaki University, Professor Taiki AOSHI)
• Innovative alpha therapy targeting PSMA for refractory prostate cancer (Department of Radiology, Graduate School of Medicine, Associate Professor (Lecturer) Tadashi WATABE)
• Targeted alpha-ray therapy for refractory thyroid cancer (Department of Radiology, Graduate School of Medicine, Associate Professor (Lecturer) Tadashi WATABE)
• Development of a new treatment for chemotherapy-resistant triple-negative breast cancer (Department of Advanced Molecular Therapy, Graduate School of Medicine, Professor Yoshiaki TANIYAMA)

Drugs (Brain and Psychiatry)

• Development of ASOs for multiple system atrophy (Department of Neurology, Graduate school of Medicine, Assistant Professor Yasuyoshi KIMURA, Professor Hideki MOCHIZUKI)

Drugs (Intractable diseases)

• Development of inhibitors of protein phosphatases involved in neurodegenerative diseases and investigation of their effects in animal models (The department of Biological Control, RIMD, Specially Appointed Assistant Professor Shizuka ISHITANI)

Drugs (Cardiovascular diseases)

• Novel therapeutic strategy for cerebral stroke using Npas4-related factors (Graduate school of medicine, Professor Taiichi KATAYAMA, Graduate school of pharmaceutical sciences, Guest Professor Akio TSUBOI)
• Development of novel companion PET diagnostics and therapeutic agents for myocarditis (Department of Cardiovascular Medicine, Graduate School of Medicine, Associate Professor Ken MATSUOKA)

Drugs (Infectious diseases)

• Clinical Development of NPC-BKSE36/CpG Malaria Vaccine (Department of Malaria Vaccine Development, Research Institute for Microbial Diseases, Endowed Chair Professor Toshihiro HORII)

Drugs (Others)

• Development of single-molecule imaging-based screening technology for drug discovery (Graduate School of Frontier Biosciences, Professor Masahiro UEDA)
• Development of repair therapy for skin barrier function by product lipids of novel lipase (Department of Bio-system Pharmacology, Graduate School of medicine, Associate Professor Ryuichi OHGAKI)
• Establishment of a new strategy for the treatment of functional restoration in skeletal muscle injury by tissue engineering using osteopontinederived SVVYGLR peptide (Department of Oral and Maxillofacial Surgery, Graduate School of Dentistry, Professor Susumu TANAKA)
• A new anti-inflammatory drug that utilizes the active site of an endogenous NFkB direct inhibitory protein (Department of Obstetrics & Gynecology, Graduate School of Medicine, Guest Associate Professor Kazuki OKAMOTO)

Medical devices

• Development of a new disinfection device using Pernitric acid solution (Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Associate Professor Katsuhisa KITANO)
• Raman spectroscopic tissue detection for minimally-invasive and precise medicine (Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, Associate Professor Yasuaki KUMAMOTO)
• Construction of the rapid detection system of gut bacterium for health awareness improvement (Life and Medical Photonics Division, Institute for Open and Transdisciplinary Research Initiatives, Specially Appointed Associate Professor Masato SAITO)
• Novel diagnostic marker to differentiate urogenital carcinoma by chiral amino acids in body fluids (Department of Urology Graduate School of Medicine, Associate Professor (Lecturer) Atsunari KAWASHIMA)
• SPECT system for boron neutron capture therapy (BNCT-SPECT) for real-time measurement of therapeutic effect (Division of Sustainable Energy and Environmental Engineering, Graduate School of Engineering, Professor Isao MURATA)
• Development of “peptide” pulp capping agent promoting wound healing process of pulp tissue (The University of Osaka Dental Hospital, Associate Professor (Lecturer) Yusuke TAKAHASHI)
• Restoration of Motor and Communication by Wireless Implantable Brain Machine Interfaces (Department of Neurological Diagnosis and Restoration, Graduate School of Medicine, Specially Appointed Professor Masayuki HIRATA)
• Development of a robot arm for bone processing (Department of Orthopaedic Surgery, Graduate School of Medicine, Associate Professor (Lecturer) Takahito FUJIMORI)

Regenerative medicine

• Repair of incurable meniscal injuries using an aligned electrospun nanofibrous scaffold combined with mesenchymal stem cells (Department of Orthopaedic Surgery, Graduate School of Medicine, Guest Professor Kazunori SHIMOMURA)
• Regeneration therapy using autologous bone marrow derived M2 macrophage for severe heart failure (The University of Osaka Hospital, Assistant Professor Kizuku YAMASHITA)
• Development of a novel therapy for α-synucleinopathy using regulatory T cells (Department of Neurology, Graduate school of Medicine, Attending Staff (Physician) Yuto HAYASHI, Professor Hideki MOCHIZUKI)
• Development of oncolytic adenovirus agents composed of human adenovirus type 35 (Graduate School of Pharmaceutical Sciences, Professor Hiroyuki MIZUGUCHI)
• Development of Liver Assist Device Using Hypoimmunogenic Hepatocyte System (Graduate School of Medicine, Professor Takanori TAKEBE)

Diagnostics

• Development of a New Method for Detection of Effects Induced by Maternal Immune Activation (Department of Neuroscience and Cell Biology, Graduate School of Medicine, Professor Shoichi SHIMADA)
• Development of pathological periostin measurement device (Department of Advanced Molecular Therapy, Graduate School of Medicine, Professor Yoshiaki TANIYAMA)
• Development of a diagnostic method for patients with chronic inflammatory disease using analysis of sugar chains of IgGs (Department of Biopathological Information Science, Graduate School of Medicine, Professor Eiji MIYOSHI)

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